1. Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease? Best Pract Res Clin Rheumatol. 2010;24(1):15-26. doi:10.1016/j.berh.2009.08.006
2. International Cartilage Regeneration & Joint Preservation Society. ICRS cartilage injury evaluation package. Accessed June 1, 2026. https://cartilage.org/wp-content/uploads/2024/07/ICRS_evaluation1-1.pdf
3. Mayo Clinic Orthopedics and Sports Medicine. Knee cartilage lesions. Accessed May 19, 2026. https://sportsmedicine.mayoclinic.org/condition/cartilage-lesions/#:~:text=Cartilage%20damage%20is%20most%20frequently,of%20the%20shock%20absorber%20function
4. Lai WC, Bohlen HL, Fackler NP, Wang D. Osteochondral allografts in knee surgery: narrative review of evidence to date. Orthop Res Rev. 2022;14:263-274. doi:10.2147/ORR.S253761
5. Salzmann GM, Ossendorff R, Gilat R, Cole BJ. Autologous minced cartilage implantation for treatment of chondral and osteochondral lesions in the knee joint: an overview. Cartilage. 2021;13(1_suppl):1124S-1136S. doi:10.1177/1947603520942952
6. Cole BJ, Haunschild ED, Carter T, et al. Clinically significant outcomes following the treatment of focal cartilage defects of the knee with microfracture augmentation using cartilage allograft extracellular matrix: a multicenter prospective study. Arthroscopy. 2021;37(5):1512-1521. doi:10.1016/j.arthro.2021.01.043
7. Tan EW, Guyton GP, Miller SD. Cartilage mesh augmentation technique for treatment of osteochondral lesions of the talus. Tech Foot Ankle Surg. 2015;14(4):188-193. doi:10.1097/BTF.0000000000000107
8. Cedars Sinai. Cartilage restoration using osteochondral allograft transfer. Accessed May 19, 2026. https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cartilage-restoration-using-osteochondral-autograft-transfer.html
9. Seo S, Kim C, Jung D. Management of focal chondral lesion in the knee joint. Knee Surg Relat Res. 2011;23(4):185-96. doi:10.5792/ksrr.2011.23.4.185 
10. Riboh J, Cvetanovich G, Cole B, Yanke A. Comparative efficacy of cartilage repair procedures in the knee: a network meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25(12):3786-99. doi:10.1007/s00167-016-4300-1
11. Krych AJ, Pareek A, King AH, Johnson NR, Stuart MJ, Williams RJ 3rd. Return to sport after the surgical management of articular cartilage lesions in the knee: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25(10):3186-3196. doi:10.1007/s00167-016-4262-3
12. Alexeev M, Kercher JS. Autograft or allograft? American Academy of Orthopedic Surgeons. Published October 1, 2019. Accessed May 19, 2026. https://www.aaos.org/aaosnow/2019/oct/clinical/clinical01/
13. Lai WC, Bohlen HL, Fackler NP, Wang D. Osteochondral allografts in knee surgery: narrative review of evidence to date. Orthop Res Rev. 2022;14:263-274. doi:10.2147/ORR.S253761
14. Gaul F, Tírico LEP, McCauley JC, Pulido PA, Bugbee WD. Osteochondral allograft transplantation for osteochondral lesions of the talus: midterm follow-up. Foot Ankle Int. 2019;40(2):202-209. doi:10.1177/1071100718805064
15. American Association of Tissue Banks. AATB standards for tissue banking. Accessed May 19, 2026. https://www.aatb.org/standards
16. Kasik CS, Martinkovich S, Mosier B, Akhavan S. Short-term outcomes for the biologic treatment of bone marrow edema of the knee using bone marrow aspirate concentrate and injectable demineralized bone matrix. Arthrosc Sports Med Rehabil. 2019;1(1):e7-e14. doi:10.1016/j.asmr.2019.07.001
17. Martin JR, Houdek MT, Sierra RJ. Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis. Croat Med J. 2013;54(3):219-224. doi:10.3325/cmj.2013.54.219
18. Tanamas SK, Wluka AE, Pelletier JP, et al. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology (Oxford). 2010;49(12):2413-2419. doi:10.1093/rheumatology/keq286

‍

1. Cedars-Sinai. Osteochondral lesions/osteochondral dessicans. Accessed March 27, 2024. https://www.cedars-sinai.org/health-library/diseases-and-conditions/o/osteochondral-lesionsosteochondritis-dessicans.html
2. Shane Anderson A, Loeser RF. Why is osteoarthritis an age-related disease?.  Best Pract Res Clin Rheumatol. 2010;24(1):15-26. doi:10.1016/j.berh.2009.08.006
3. Mayo Clinic Orthopedic and Sports Medicine. Knee cartilage lesions. Accessed March 18, 2024. https://sportsmedicine.mayoclinic.org/condition/cartilage-lesions/#:~:text=Cartilage%20damage%20is%20most%20frequently,of%20the%20shock%20absorber%20function
4. American Association of Tissue Banks. AATB Standards for Tissue Banking. Accessed March 18, 2024. https://www.aatb.org/standards
5. Allograft bioimplant. Directions for use (63-0016-01 Rev. 10). LifeNet Health.
6. Torrie AM, Kesler WW, Elkin J, Gallo RA. Osteochondral allograft. Curr Rev Musculoskelet Med. 2015;8(4):413-422. doi:10.1007/s12178-015-9298-3
7. Steadman JR, Rodkey WG, Briggs KK. Microfracture: its history and experience of the developing surgeon. Cartilage. 2010;1(2):78-86. doi:10.1177/1947603510365533
8. Cole BJ, Farr J, Winalski CS, et al. Outcomes after a single-stage procedure for cell-based cartilage repair: a prospective clinical safety trial with 2-year follow-up.  Am J Sports Med. 2011;39(6):1170-1179. doi:10.1177/0363546511399382
9. Krych AJ, Pareek A, King AH, Johnson NR, Stuart MJ, Williams RJ 3rd. Return to sport after the surgical management of articular cartilage lesions in the knee: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25(10):3186-3196. doi:10.1007/s00167-016-4262-3 
10. Haber DB, Logan CA, Murphy CP, Sanchez A, LaPrade RF, Provencher MT. Osteochondral allograft transplantation for the knee: postoperative rehabilitation. Int J Sports Phys Ther. 2019;14(3):487-499. doi:10.26603/ijspt20190487
11. Zúñiga CAV, De Cicco FL. Osteochondral allograft. StatPearls Publishing. Updated July 31, 2023. Accessed March 27, 2024. https://www.ncbi.nlm.nih.gov/books/NBK560511/

1. Allograft bioimplant. Directions for use (63-0016-01 Rev. 10). LifeNet Health.

1. Cole BJ, Haunschild ED, Carter T, et al. Clinically significant outcomes following the treatment of focal cartilage defects of the knee with microfracture augmentation using cartilage allograft extracellular matrix: a multicenter prospective study. Arthroscopy. 2021;37(5):1512-1521. doi:10.1016/j.arthro.2021.01.043 
2. Schneider S, Ossendorff R, Walter SG, et al. Arthroscopic autologous minced cartilage implantation of cartilage defects in the knee: a 2-year follow-up of 62 patients. Orthop J Sports Med. 2024;12(12):23259671241297970. doi:10.1177/23259671241297970 
3. Levinson C, Cavalli E, Sindi DM, et al. Chondrocytes from device-minced articular cartilage show potent outgrowth into fibrin and collagen hydrogels. Orthop J Sports Med. 2019;7(9):2325967119867618. doi:10.1177/2325967119867618 

1. Lai WC, Bohlen HL, Fackler NP, Wang D. Osteochondral allografts in knee surgery: narrative review of evidence to date. Orthop Res Rev. 2022;14:263-274. doi:10.2147/ORR.S253761
2. Allograft bioimplant. Directions for use (63-0016-01 Rev. 10). LifeNet Health.
3. Cedars Sinai. Cartilage restoration using osteochondral allograft transfer. Accessed March 27, 2026. https://www.cedars-sinai.org/health-library/diseases-and-conditions/c/cartilage-restoration-using-osteochondral-autograft-transfer.html‍
4. Seo S, Kim C, Jung D. Management of focal chondral lesion in the knee joint. Knee Surg Relat Res. 2011;23(4):185-96. doi:10.5792/ksrr.2011.23.4.185
5. Riboh J, Cvetanovich G, Cole B, Yanke A. Comparative efficacy of cartilage repair procedures in the knee: a network meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25(12):3786-99. doi:10.1007/s00167-016-4300-1
6. Krych AJ, Pareek A, King AH, Johnson NR, Stuart MJ, Williams RJ 3rd. Return to sport after the surgical management of articular cartilage lesions in the knee: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2017;25(10):3186-3196. doi:10.1007/s00167-016-4262-3
7. Alexeev M, Kercher JS. Autograft or allograft? American Academy of Orthopedic Surgeons. Published October 1, 2019. Accessed March 27, 2026. https://www.aaos.org/aaosnow/2019/oct/clinical/clinical01/
8. Rönn K, Reischl N, Gautier E, Jacobi M. Current surgical treatment of knee osteoarthritis. Arthritis.2011;2011:454873. doi:10.1155/2011/454873

1. Rönn K, Reischl N, Gautier E, Jacobi M. Current surgical treatment of knee osteoarthritis. Arthritis. 2011;2011:454873. doi:10.1155/2011/454873 

1. Hernigou P, Poignard A, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 2005;87(7):1430-1437. doi:10.2106/JBJS.D.02215
2. Hernigou P, Mathieu G, Poignard A, Manicom O, Beaujean F, Rouard H. Percutaneous autologous bone-marrow grafting for nonunions. Surgical technique.  J Bone Joint Surg Am. 2006;88 Suppl 1 Pt 2:322-327. doi:10.2106/JBJS.F.00203
3. Martin JR, Houdek MT, Sierra RJ. Use of concentrated bone marrow aspirate and platelet rich plasma during minimally invasive decompression of the femoral head in the treatment of osteonecrosis. Croat Med J. 2013;54(3):219-224. doi:10.3325/cmj.2013.54.219 
4. Tanamas SK, Wluka AE, Pelletier JP, et al. Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study. Rheumatology (Oxford). 2010;49(12):2413-2419. doi:10.1093/rheumatology/keq286 
5. Sánchez M, Delgado D, Sánchez P, et al. Combination of intra-articular and intraosseous injections of platelet rich plasma for severe knee osteoarthritis: a pilot study. Biomed Res Int. 2016;2016:4868613. doi:10.1155/2016/4868613 
6. Rönn K, Reischl N, Gautier E, Jacobi M. Current surgical treatment of knee osteoarthritis. Arthritis. 2011;2011:454873. doi:10.1155/2011/454873